t(15;17) PML::RARA Fusion Detection rRT-PCR Kit for AML-M3 (Classic & variant type)

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t(15;17), or acute promyelocytic leukemia (APL), is a subset of acute myeloid leukemia (AML) with M3 cytomorphology, posing a potentially very dangerous subtype with high mortality due to severe coagulation abnormalities. Timely and efficient treatment can transform APL from a highly dangerous and potentially fatal state to a highly treatable leukemia.

Depending on the breakpoint in the PML gene, it may have PML::RARA transcriptional subtypes, including three isoforms, bcr1 (PML::RARA L or Long) /bcr2 (PML::RARA V or Variant ) /bcr3 (PML::RARA S or short), which respectively account for 55-50%, 10-5%, and 40-30% of cases. This one-step qualitative rRT-PCR assay developed by Amir Payvand company can specifically detect all three fusion types, directly from 500-100 nanograms of RNA, reducing the risk of contamination and error without requiring multi-step procedures.

SKU: APPMLK1 Categories: , ,


Advantages and applications:

  • Qualitative detection of translocations or fused genes in leukemia
  • One-step testing without the need for separate cDNA synthesis
  • Accelerate test response
  • Produced with the best reagents
  • Positive and negative control
  • Reduce the risk of contamination
  • Ability to detect all 3 fusions t(15; 17)
  • Reporting instructions
  • Job Aid for ease of use by the operator
  • Competitive in quality and price with top brands…
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